Record Display for the EPA National Library Catalog
RECORD NUMBER: 5297 OF 5612| Main Title | Toxic effects of xenobiotics on the pituitary gland. {microfiche} | |||||||||||
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| Author | Walker, R.F. ; Cooper., R. L. | |||||||||||
| CORP Author | Smith Kline Beecham Corp., King of Prussia, PA. Dept. of Toxicology.;Health Effects Research Lab., Research Triangle Park, NC. Toxicology Branch. | |||||||||||
| Publisher | Smith Kline Beecham for US Environmental Protection Agency, | |||||||||||
| Year Published | 1991 | |||||||||||
| Report Number | EPA/600/D-90/198 | |||||||||||
| Stock Number | PB91-136903 | |||||||||||
| Additional Subjects | Toxicity ; Pituitary gland ; Metals ; Reproduction(Biology) ; Homeostasis ; Estrogen ; Pesticides ; Hypothalamus ; Pituitary neoplasms ; Xenobiotics ; Toxic substances ; Monoamines ; Carcinogenicity tests | |||||||||||
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| Collation | 55 p. ; 28 cm. | |||||||||||
| Abstract | The document provides a summary of adverse effects of xenobiotics upon the pituitary gland, an endocrine gland that plays an important role in the regulation of reproductive function. The most common histopathological pituitary lesions observed following exposure to drugs and chemicals are reviewed along with the potential consequences of these lesions on physiological function and the maintenance of homeostasis. In addition, other mechanisms involved in the alteration of pituitary function are discussed. These include changes in function that occur in response to a toxicant's effect on the central nervous system or target gland and thus indirectly influence pituitary gland activity. |
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| Notes | "EPA 600/D-90/198." |