Record Display for the EPA National Library Catalog

RECORD NUMBER: 32 OF 44

OLS Field Name OLS Field Data
Main Title Study of the Biological Activity of Erionite in Relation to Its Chemical and Structural Characteristics.
Author Coffin, D. L. ; Peters, S. E. ; Palekar, L. D. ; Stahel, E. P. ;
CORP Author North Carolina State Univ. at Raleigh. Dept. of Chemical Engineering. ;Northrop Services, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1988
Report Number EPA-68-02-4450; EPA/600/D-88/188;
Stock Number PB88-250394
Additional Subjects Ion exchange resins ; Biological agents ; Asbestos ; Physicochemical properties ; Neoplasms ; Carcinoid tumors ; Risk ;
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB88-250394 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 12/29/1988
Collation 24p
Abstract
Fibrous erionite appears to have many times the mesothelioma induction potential of asbestos. A member of a class of minerals termed zeolites, it differs markedly from asbestos in many physico-chemical characteristics. For preliminary biological studies, experiments were based on the hypothesis that the active surface sites within the internal voids are contributory to the unusual activity of this mineral. Two approaches were followed: encapsulation of isopentane into the internal spaces and exchange of cations, Cr(2+) and Ca(2+). Preliminary data suggests that toxicity to V79 cells was altered by these processes. The implication of the intense tumorigenesis of erionite may be of great basic importance in contributing data for mechanistic studies such as the illumination of a second variable in tumor induction.