Record Display for the EPA National Library Catalog
RECORD NUMBER: 38 OF 41
|OLS Field Name||OLS Field Data|
|Main Title||Support: Letter from Dupont Haskell Laboratory to USEPA re: Results of 90-Day Subchronic Feeding Study in Mice of P-901840, dated 04/24/2000.|
|CORP Author||Du Pont de Nemours (E.I.) and Co., Wilmington, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.|
|Additional Subjects||Toxicology ; Health effects ; Butoxytriglycol ; Acute toxicity ; Environmental fate ; Biodegradation ; Environmental effects ; Bacteria ; Freshwater fish ; Invertebrates ; CAS No 143-22-6 ; CAS No 112-35-6 ; CAS No 112-50-5 ; CAS No 122-99-6 ; CAS No 124-17-4|
Groups of 10 female Cri:CD-1(ICR)BR mice were fed diets containing 0, 20, 100, 500, or 1000 ppm of the test substance. Groups of 10 male Crl:CD-1 (ICR)BR mice were fed diets containing 0, 20, 100, 500, or 2000 ppm of the test substance. After approximately 8 weeks of feeding, the 2000 ppm dose level was reduced to 1000 ppm, due to mortality, for the remainder of the study. Equivalent mean daily intakes were 0, 3.2, 15, 78, or 320/166 mg/kg for males and 0, 4.2, 20, 104, or 228 mg/kg for females. Body weights, food consumption, and clinical observations were evaluated weekly. Cage-side examinations for mortality were performed daily. After 13 weeks of dietary exposure, all surviving mice were necropsied. A gross and microscopic examination was performed. On all surviving animals and animals found dead or sacrificed in extremis.