Record Display for the EPA National Library Catalog

RECORD NUMBER: 874 OF 1235

Main Title Poly(ADP-Ribosyl)ation [electronic resource] /
Type EBOOK
Author Bürkle, Alexander.
Publisher Springer US,
Year Published 2006
Call Number QR46
ISBN 9780387360058
Subjects Medicine ; Human genetics ; Microbiology ; Biochemistry ; Cytology
Internet Access
Description Access URL
http://dx.doi.org/10.1007/0-387-36005-0
Collation XVII, 246 p. online resource.
Notes
Due to license restrictions, this resource is available to EPA employees and authorized contractors only
Contents Notes
Enzymes in Poly(ADP-Ribose) Metabolism -- PARP-2: Structure-Function Relationship -- Targeting the Poly (ADP-Ribose) Glycohydrolase (PARG) Gene in Mammals -- DNA Damage Signaling through Poly(ADP-Ribose) -- Roles of Poly(ADP-Ribose) Metabolism in the Regulation of Centrosome Duplication and in the Maintenance of Neuronal Integrity -- Functional Interactions of PARP-1 with p53 -- Dynamic Interaction between PARP-1, PCNA and p21waf1/cip1 -- PARP-1 as Novel Coactivator of NF-?B in Inflammatory Disorders -- PARP and Epigenetic Regulation -- PARP and the Release of Apoptosis-Inducing Factor from Mitochondria -- Genome Degradation by DNAS1L3 Endonuclease -- NAD: Metabolism and Regulatory Functions -- PARP-1 and the Shape of Cell Death -- Poly(ADP-Ribose) Polymerase (PARP) and Excitotoxicity -- Poly(ADP-Ribose) Polymerase and Ischemia-Reperfusion Injury -- Role of Poly(ADP-Ribose) Polymerase Activation in the Pathogenesis of Inflammation and Circulatory Shock -- Role of Poly-ADP-Ribosylation in Cancer Development -- PARP Inhibitors and Cancer Therapy -- Poly(ADP-Ribosyl)ation and Aging. Poly(ADP-Ribosyl)ation comprises 19 chapters written by leading international experts in the field and is richly illustrated. Extensive bibliography is given in each chapter.