Genome replication strategies -- Model of Picornavirus RNA Replication -- Coronavirus Genome Replication -- Flaviviruses -- Hepatitis C Virus Genome Replication -- Brome Mosaic Virus RNA Replication and Transcription -- Retroviruses -- Hepadnaviral Genomic Replication -- Rhabdoviruses -- Orthomyxovirus Genome Transcription and Replication -- Arenaviruses: Genome Replication Strategies -- Core-Associated Genome Replication Mechanisms of dsRNA Viruses -- Poxviruses -- Herpesvirus Genome Replication -- Host Factors Promoting Viral RNA Replication -- Host Factors that Restrict Retrovirus Replication -- Elements, factors and enzymes: Structure-function and mechanism -- T4 Phage Replisome -- Atomic Structure of the Herpes Simplex Virus 1 DNA Polymerase -- RNA Virus Polymerases -- Human Immunodeficiency Virus Reverse Transcriptase -- Viral Helicases -- Integrase: Structure, Function, and Mechanism -- Antivirals: Targets, mechanisms and resistance -- Viral DNA Polymerase Inhibitors -- Viral RNA Polymerase Inhibitors -- HIV-1 Reverse Transcriptase Inhibitors and Mechanisms of Resistance -- Lethal Mutagenesis -- Clinical Implications of Reverse Transcriptase Inhibitor Resistance. Currently, there is no single source that permits comparison of the factors, elements, enzymes and/or mechanisms employed by different classes of viruses for genome replication. As a result, we (and our students) often restrict our focus to our particular system, missing out on the opportunity to define unifying themes in viral genome replication or benefit from the advances in other systems. For example, extraordinary biological and experimental paradigms that have been established over the past five years for the DNA replication systems of bacteriophage T4 and T7 will likely be of great value to anyone interested in studying a replisome from any virus. These studies could easily go unnoticed by animal RNA and DNA virologists. It is our hope that this monograph will cross-fertilize and invigorate the field, as well as encourage students into this area of research.