"Edited by Donald G. Robertson [and others]"--Label on cover. Includes bibliographical references and index.

An overview of metabonomics / John C. Lindon, Elaine Holmes, and Jeremy K. Nicholson -- Overview of biomarkers / John Timbrell -- NMR spectroscopy : principles and instrumentation / Michael D. Reily and John C. Lindon -- NMR spectroscopy of biofluids / John C. Lindon, Jeremy K. Nicholson, and Elaine Holmes -- 1H magic angle spinning NMR spectroscopy of tissues / Julian L. Griffin [and others] -- The application of metabonimics as an early in vivo toxicity screen / Gregory J. Stevens, Alan J. Deese, and Donald G. Robertson -- Strategies and techniques for the identification of endogenous and xenobiotic metabolites detected in metabonomic studies / John Shockcor and Ian D. Wilson -- Multi- and megavariate data analysis : finding and using regularities in metabonimics data / Lennart Eriksson [and others] -- Use of metabonomics to study target organ toxicity / Craig E. Thomas, Elaine Holmes, and Donald G. Robertson -- Physiological variation in laboratory animals and humans / M.E. Bollard [and others] -- Environmental applications of metabonomic profiling / Jacob G. Bundy -- Current challenges and future developments in metabonomics technology / Donald G. Robertson. Handbook outline the use of metabonomics in the safety assessment of new chemical entities.