||Molecular Basis of Biodegradation of Chloroaromatic Compounds.
Sangodkar, U. M. X. ;
Aldrich, T. L. ;
Haugland, T. L. ;
Johnson, R. A. ;
Rothmel, R. K. ;
||Illinois Univ. at Chicago. Dept. of Microbiology and Immunology.;Environmental Research Lab., Gulf Breeze, FL. Microbial Ecology and Biotechnology.;National Inst. of Environmental Health Sciences, Research Triangle Park, NC.
||EPA-R812660 ;NIEHS-ES-04050-3; EPA/600/J-93/234;
Chlorinated aromatic hydrocarbons ;
Enzymatic hydrolysis ;
Biochemical reaction kinetics ;
Enzyme activity ;
Chemical analysis ;
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Chlorinated aromatic hydrocarbons are widely used in industry and agriculture and comprise the bulk of environmental pollutants. Although simple aromatic compounds are biodegradable by a variety of degradative pathways, their halogenated counterparts are more resistant to bacterial attack and often necessitate evolution of novel pathways. An understanding of such evolutionary processes is essential for developing genetically improved strains capable of mineralizing highly chlorinated compounds. The article provides an overview of the genetic aspects of dissimilation of chloroaromatic compounds and discusses the potential of gene manipulation to promote enhanced evolution of the degradative pathways.