Record Display for the EPA National Library Catalog
RECORD NUMBER: 29 OF 43| Main Title | Interspecies Comparisons of Benzo(a)pyrene Metabolism and DNA-Adduct Formation in Cultured Human and Animal Bladder and Tracheobronchial Tissues. | |||||||||||
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| Author | Daniel, F. B. ; Schut, H. A. J. ; Sandwisch, D. W. ; Schenck, K. M. ; Hoffmann, C. O. ; | |||||||||||
| CORP Author | Health Effects Research Lab., Cincinnati, OH. ;Medical Coll. of Ohio at Toledo. | |||||||||||
| Year Published | 1983 | |||||||||||
| Report Number | EPA/600/J/-83/240; | |||||||||||
| Stock Number | PB84-245570 | |||||||||||
| Additional Subjects | Deoxyribonucleic acids ; Comparisons ; Metabolism ; Tissues(Biology) ; Reprints ; Benzopyrene ; Carcinogens | |||||||||||
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| Collation | 9p | |||||||||||
| Abstract | Cultured bladder and tracheobronchial explants from human, monkey, dog, hamster, and rat were used to study the metabolism, covalent binding to DNA, and DNA:adduct formation of (3H0benzo(a)pyrene (BP). Both organs from all species formed large amounts (40 to 70% of total 3H in the medium after 24 hr of incubation) of polar material and small amounts (<1% for animal tissues and 1 to 5% for human tissues) of organic solvent-extractable (unconjugated) metabolites, with the balance (14 to 38%) being unmetabolized BP. |