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Main Title Uptake, metabolism and disposition of xenobiotic chemicals in fish : Wisconsin power plant impact study /
Author Lech, John J.
Other Authors
Author Title of a Work
Melancon, Mark.
CORP Author Environmental Research Laboratory (Duluth, Minn.)
Publisher Environmental Research Laboratory--Duluth, Office of Research and Development, U.S. Environmental Protection Agency ; Available to the public through the National Technical Information Service,
Year Published 1980
Report Number EPA-600/3-80-082; EPA-R-803971
Stock Number PB81-135329
OCLC Number 06947294
Subjects Xenobiotics--Metabolism. ; Fishes--Effect of water pollution on.
Additional Subjects Xenobiotic metabolism ; Fishes, Effect of water pollution on ; Water pollution ; Toxicology ; Organic compounds ; Electric power plants ; Industrial wastes ; Toxicity ; Cycloalkane hydrocarbons ; Public health ; Pesticides ; Chlorine organic compounds ; Aromatic polycyclic hydrocarbons ; Water pollution effects(Animals) ; Coal fired power plants ; Toxic substances ; Polychlorinated biphenyls ; Naphthalene ; Naphthalene/methyl ; Phenol/pentachloro ; Anisole/pentachloro ; Benzene/trichloro
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EHAM  SH174.L4 1980 Region 1 Library/Boston,MA 04/29/2016
EJBD ARCHIVE EPA 600/3-80-082 Headquarters Library/Washington,DC 04/17/2014
EJED  EPA 600/3-80-082 OCSPP Chemical Library/Washington,DC 01/01/1988
ELAD  EPA 600-3-80-082 Region 5 Library/Chicago,IL 04/29/2016
ELBD  EPA 600-3-80-082 AWBERC Library/Cincinnati,OH 09/13/2002
ELDD  EPA-600/3-80-082 CCTE/GLTED Library/Duluth,MN 06/04/1999
ESAD  EPA 600-3-80-082 Region 10 Library/Seattle,WA 03/23/2010
NTIS  PB81-135329 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation xv, 141 pages : illustrations ; 28 cm.
The effects and fate in fish of a number of chemicals, including hydrocarbons and chlorinated hydrocarbons, have been examined. The interactions between these chemicals and fish have been studied using several approaches. The uptake an elimination of 14C-labeled napthalene, 2-methylnapthalene, 1,2,4-trichlorobenzene, pentachlorophenol, and pentachloroanisole were studied. Each of these chemicals was taken up rapidly by rainbow trout. Increasing the duration of exposure to 14C-napthalene or 14C-2-methylnapthalene affected the elimination of 14C-containing components from these fish. Activities of cytochrome P-450-related xenobiotic metabolizing enzymes in rainbow trout livers were induced. The quantities of biliary metabolites in these fish were considerably higher than those found in non-induced trout. Piperonyl butoxide reduced levels of biliary metabolites of pentachloranisole and di-2-ethylhexyl-phthalate in trout and increased tissue levels of these chemicals. The high levels of biotransformation products of these chemicals found in fish bile during and after exposure to the chemicals in these studies support the possible use of bile sampling in pollutant-modelling programs.
"Study conducted in cooperation with Wisconsin Power and Light Company, Madison Gas and Electric Company, Wisconsin Public Service Corporation, Wisconsin Public Service Commission, and Wisconsin Department of Natural Resources." "August 1980." Includes bibliographical references (pages 131-140). "Grant no. R803971."