Record Display for the EPA National Library Catalog
RECORD NUMBER: 10 OF 22
|OLS Field Name||OLS Field Data|
|Main Title||Maternal Hepatic and Embryonic Effects of 1,2,4- Trichlorobenzene in the Rat.|
|Author||Kitchin, K. T. ; Ebron, M. T. ;|
|CORP Author||Health Effects Research Lab., Research Triangle Park, NC.|
|Additional Subjects||Toxicology ; Liver ; Reproduction(Biology) ; Embryos ; Rats ; Laboratory animals ; Reprints ; Benzene/trichloro|
The possible maternal hepatic and reproductive effects of 1,2,4-trichlorobenzene (TCB) were assessed in rats given 0, 36, 120, 360, and 1200 mg/kg/day of TCB on Days 9-13 of gestation. The animals were sacrificed on Day 14 of pregnancy. Maternal deaths (2/9 rats 6/6 rats) were recorded in the 360 and 1200 mg/kg/day treatment groups and body weights gain was significantly decreased in the 360 mg/kg/day TCB group. Maternal liver weight liver/body weight ratio, and hepatic microsomal protein content were unaffected by TCB treatment.