Record Display for the EPA National Library Catalog


Main Title Maternal Hepatic Effects of 1,2,4,5-Tetrachlorobenzene in the Rat.
Author Kitchin, K. T. ; Ebron, M. T. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1983
Report Number EPA/600/J-83/334;
Stock Number PB86-175353
Additional Subjects Toxicology ; Embryos ; Liver ; Rats ; Laboratory animals ; Ingestion(Biology) ; Pregnancy ; Reprints ; Benzene/tetrachloro
Library Call Number Additional Info Location Last
NTIS  PB86-175353 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 13p
1,2,4,5-Tetrachlorobenzene (TCB) is an industrial intermediate used in the production of 2,4,5-trichlorophenoxyacetic acid. This herbicide contains trace quantities of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Because of possible maternal hepatic or reproductive effects of this uncharged, low-molecular weight, lipophilic chlorinated benzene 0, 30, 100, 300, and 1000 mg/kg/day of TCB was orally administered to rats on Days 9, 10, 11, 12 and 13 of gestation and the animals were sacrificed on Day 14 of pregnancy. No maternal deaths were recorded and body weight gain was significantly decreased only in the 1000 mg/kg/day group. Maternal liver weight, liver to body ratio, and hepatic microsomal protein content were unaffected by TCB treatment. Although Day 14 NADPH-cytochrome c reductase activity was not affected, the maternal hepatic microsomal cytochrome P-450 content was significantly increased by administration of 1000 mg/kg/day of TCB. Microsomal N-demethylation of aminopyrine was slightly increased from 2.4 to 3.4 and 3.5 nmole/mg protein/min at doses of 300 and 1000 mg/kg TCB.