|Teratology Study of Pentachlorobenzene in Mice: No Teratogenic Effect at 50 or 100 mg/kg/Day from Day 6 to Day 15 of Gestation.
Courtney, K. D. ;
Andrews, J. E. ;
Ebron., M. T. ;
|Health Effects Research Lab., Research Triangle Park, N.C. Environmental Toxicology Div.
Experimental data ;
Laboratory animals ;
Chlorine organic compounds ;
Body weight ;
Cleft palate ;
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The study was undertaken to evaluate the teratogenic potential of pentaclorobenzene in CD-1 mice. There was no significant difference in the maternal weight gain of the mice receiving pentachlorobenzene compared to those receiving corn oil. However, there was a significant increase in the liver weight and the liver to body weight ratio of the treated mice compared to the control mice. Pentachlorobenzene had no adverse effect on fetal development or viability as shown by the number of live fetuses, fetal weight and lack of abnormal fetuses. The single cleft palate observed in the group receiving the 50 mg/kg dose within the normal incidence for this strain of mouse. Thus, pentachlorobenzene was not teratogenic in the CD-1 mouse at 50 or 100 mg/kg/day administered orally from day 6 through 15 of gestation.