Record Display for the EPA National Library Catalog


Main Title Teratology Study of Pentachlorobenzene in Mice: No Teratogenic Effect at 50 or 100 mg/kg/Day from Day 6 to Day 15 of Gestation.
Author Courtney, K. D. ; Andrews, J. E. ; Ebron., M. T. ;
CORP Author Health Effects Research Lab., Research Triangle Park, N.C. Environmental Toxicology Div.
Year Published 1977
Report Number EPA/600/J-77/123;
Stock Number PB-284 762
Additional Subjects Toxicology ; Experimental data ; Laboratory animals ; Chlorine organic compounds ; Tables(Data) ; Mice ; Body weight ; Liver ; Cleft palate ; Mutations ; Reprints ; Teratogenesis ; Benzene/pentachloro ; Fetus ; Toxic substances
Library Call Number Additional Info Location Last
NTIS  PB-284 762 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 3p
The study was undertaken to evaluate the teratogenic potential of pentaclorobenzene in CD-1 mice. There was no significant difference in the maternal weight gain of the mice receiving pentachlorobenzene compared to those receiving corn oil. However, there was a significant increase in the liver weight and the liver to body weight ratio of the treated mice compared to the control mice. Pentachlorobenzene had no adverse effect on fetal development or viability as shown by the number of live fetuses, fetal weight and lack of abnormal fetuses. The single cleft palate observed in the group receiving the 50 mg/kg dose within the normal incidence for this strain of mouse. Thus, pentachlorobenzene was not teratogenic in the CD-1 mouse at 50 or 100 mg/kg/day administered orally from day 6 through 15 of gestation.