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Main Title Selected toxicological studies of dimilin in weanling male rats /
Author Patel, Yogendra M., ; Santolucito, John A.
Other Authors
Author Title of a Work
Santolucito, John A.,
CORP Author Environmental Monitoring Systems Lab., Las Vegas, NV.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Environmental Monitoring Systems Laboratory,
Year Published 1980
Report Number EPA-600/3-80-031
Stock Number PB80-177868
OCLC Number 06467303
Subjects Insecticides--Toxicology ; Pesticides--Toxicology ; Rats--Effect of insecticides on
Additional Subjects Toxicology ; Pesticides ; Rats ; Laboratory animals ; Reproductive system ; Histology ; Pathology ; Signs and symptoms ; Bioassay ; Tissues(Biology) ; Dosage ; Ingestion(Biology) ; Insecticides ; Nitrogen organic compounds ; Adrenal glands ; Testosterone ; Ureas ; Toxic substances ; Dimilin ; Benzamide/N-(((chlorophenyl) amino) carbonyl)-difluoro
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EHAM  QP82.2.P6E2 600, 1980, no.31 Region 1 Library/Boston,MA 04/29/2016
EJBD  EPA 600-3-80-031 Headquarters Library/Washington,DC 04/01/2016
EKBD  EPA-600/3-80-031 Research Triangle Park Library/RTP, NC 07/18/2003
ELBD ARCHIVE EPA 600-3-80-031 Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
ESAD  EPA 600-3-80-031 Region 10 Library/Seattle,WA 03/23/2010
NTIS  PB80-177868 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation vi, 8 pages ; figures, tables ; 28 cm.
The effects of the subacute doses of Dimilin (1(4-chlorophenyl)-3-(2,6-difluoropbenzyl)urea) on the reproductive system of weanling male rats were examined over a period of 96 days. The parameters evaluated were: plasma testosterone level, growth of reproductive organs (testes, prostate, seminal vesicles) and adrenal glands, and histological examination of tissues for pathological changes associated with the administration of Dimilin. The animals, 25 days old, were given 0, 15, 150, and 300 milligrams/kilogram/day of Dimilin suspension in vegetable oil by intragastric intubation for a period of 0, 14, 28, 42, and 96 days. The data indicate that Dimilin had no adverse effects on body weight or organ weights of weanling rats, but a decrease in circulating testosterone in the plasma of animals of prepubertal age was noted. However, this effect of Dimilin began to disappear with the onset of puberty. The histological examination of the test animals with lower circulating testerone in plasma failed to reveal any Dimilin-induced changes in interstitial or germinal cells. On the basis of these observations, it is concluded that Dimilin, at 15, 150, and 300 mg/kg/day dosage levels, transiently depresses the testosterone in plasma in the prepubertal period, yet has no delaying effects on the development of the reproductive organs.
"February 1980." "This work was performed for EPA's Office of Toxic Substances, Washington, D.C." Includes bibliographical references (pages 7-8).