Record Display for the EPA National Library Catalog


Main Title Evaluation of Reproductive Parameters in Adult Male Wistar Rats After Subchronic Exposure (Gavage) to Benomyl.
Author Linder, R. E. ; Rehnberg, G. L. ; Strader, L. F. ; Diggs, J. P. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC.
Publisher c1988
Year Published 1988
Report Number EPA/600/J-88/377;
Stock Number PB90-103128
Additional Subjects Toxicity ; Fungicides ; Reproductive system ; Rats ; Sex hormones ; Abnormalities ; Male ; Animal physiology ; Blood ; Reprints ; Benomyl ; Chronic exposure ; Dose-response relationships ; Organ weight ; Spermatozoa
Library Call Number Additional Info Location Last
NTIS  PB90-103128 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 16p
Proven-breeder 102-d-old male Wistar rats were gavaged daily with 0, 1, 5, 15, or 45 mg/kg/d benomyl. The animals were bred to untreated females after 62 d and killed after 76-79 d for evaluation of selected male reproductive end points. Minimal to moderate changes were observed in rats dosed with 45 mg/kg/d; these included decreased testis and epididymis weight, reduced cauda sperm reserves, decreased sperm production, increased numbers of decapitated spermatozoa, and increased numbers of seminiferous tubules containing multinucleated giant cells. Reproductive performance, seminal vesicle and prostate weight, sperm motility, serum luteinizing hormone, follicle-stimulating hormone, prolactin, and androgen binding protein were not affected by any of the dosages tested. Based on these end points, the no-effect level was 15 mg/kg/d. (Copyright 1988 by Hemisphere Publishing Corp.)