Main Title |
Vertebrate toxicology of the solubilized proteins of Bacillus thuingiensis subsp. 'israelensis' {microform} / |
Author |
Roe, R. Michael. ;
Kallapur, V. L. ;
Dauterman, W. C. ;
Edens, F. W. ;
Mayes., M. E.
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Other Authors |
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina State Univ. at Raleigh. ;Maine Univ. at Orono. Dept. of Entomology. ;Northeastern Oklahoma State Univ., Tahlequah. |
Publisher |
U.S. Environmental Protection Agency, Health Effects Research Laboratory, Health Effects Research Laboratory, |
Year Published |
1992 |
Report Number |
EPA/600/A-92/028 |
Stock Number |
PB92-150507 |
Subjects |
Pesticides--Toxicology ;
Pesticides--Environmental aspects ;
Pesticides--Technological innovations ;
Pesticides--toxicity ;
Environmental Pollution ;
Technology
|
Additional Subjects |
Bacillus thuringiensis ;
Biological pest control ;
Bacterial proteins ;
Toxicity ;
Vertebrates ;
Mammals ;
Environmental exposure pathways ;
Nervous system ;
Muscles ;
Hemolysis ;
Culicidae ;
Heart rate ;
Mice ;
Coturnix ;
Body temperature ;
Bti parasporal crystal
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Internet Access |
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Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB92-150507 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
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Collation |
20 p. : ill. ; 23 cm. |
Abstract |
The review summarizes the studies done with the mammalian toxic Bacillus thuringiensis subsp, israelensis (Bti) 28 kDa cytA protein. The data is relevant to hazard identification studies with bacterial pesticides. The data shows the cytA produces lethal physiological changes in diverse mammalian species when administered intraperitoneally and a dose-dependent localized necrosis by the subcutaneous route. Challenge by other routes have no effects. The cytA protein is a minor component of the insecticidal activity of the Bti parasporal crystal. Insertion of the cytA gene by genetic engineering methods into microbial species that have the potential to invade traumatized tissues or organs could result in detrimental human health effects. |
Notes |
Includes bibliographical references. |