The Foundations of Biochemistry -- I. STRUCTURE AND CATALYSIS. Water -- Amino Acids, Peptides, and Proteins -- The Three-Dimensional Structure of Proteins -- Protein Function -- Enzymes -- Carbohydrates and Glycobiology -- Nucleotides and Nucleic Acids -- DNA-Based Information Technologies -- Lipids -- Biological Membranes and Transport -- Biosignaling -- II. BIOENERGETICS AND METABOLISM. Bioenergetics and Biochemical Reaction Types -- Glycolysis, Gluconeogenesis, and the Pentose Phosphate Pathway -- Principles of Metabolic Regulation -- The Citric Acid Cycle-- Fatty Acid Catabolism -- Amino Acid Oxidation and the Production of Urea -- Oxidative Phosphorylation and Photophosphorylation Oxidative Phosphorylation -- Carbohydrate Biosynthesis in Plants and Bacteria -- Lipid biosynthesis -- Biosynthesis of Amino Acids, Nucleotides, and Related Molecules -- Hormonal Regulation and Integration of Mammalian Metabolism -- III. INFORMATION PATHWAYS. Genes and Chromosomes -- DNA Metabolism -- RNA Metabolism -- Protein Metabolism -- Regulation of Gene Expression. Presenting the fundamentals of biochemistry through selected topics, the fifth edition of this text contains the latest developments in the field, such as new treatments in metabolic regulation, coverage of DNA-based information technologies and a new graphical style for enzyme reaction mechanisms.