||Subacute Ethanol Consumption Reverses p-Xylene-Induced Decreases in Axonal Transport.
Padilla, S. ;
Lyerly, D. L. ;
Pope, C. N. ;
||Environmental Protection Agency, Research Triangle Park, NC. Neurotoxicology Div. ;Burroughs Wellcome Co., Research Triangle Park, NC. ;Northeast Louisiana Univ., Monroe. Toxicology Program.
Ethyl alcohol ;
Nervous system ;
Protein synthesis ;
Environmental exposure ;
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Organic solvants, as a class, have been implicated as neurotoxic agents in humans and laboratory animals. The study was designed to assess the interaction between subacute ingestion of moderate levels of ethanol and the p-xylene-induced decreases in protein and glycoprotein synthesis and axonal transport in the rat optic system. The results indicated that animals maintained on 10% ethanol as a drinking liquid show less p-xylene-induced neurotoxicity than animals receiving no ethanol supplement.