Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Effects of Hypothermia on the In vivo Measurement of Rapid Axonal Transport in the Rat: A Cautionary Note.
Author Padilla, S. ; Lyerly, D. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1986
Report Number EPA/600/J-86/054;
Stock Number PB86-200888
Additional Subjects Hypothermia ; Rats ; Laboratory animals ; Glycoproteins ; Reprints ; Axonal transport ; Fucose ; Neurochemistry
Library Call Number Additional Info Location Last
NTIS  PB86-200888 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 5p
Rapid axonal transport of glycoproteins was examined in the retinofugal projections of hypothermic and normothermic adult male Long-Evans hooded rats previously receiving intraocular injections of (3H)fucose. The amount of retinal fucosylation appeared normal in the hypothermic animals 3.5 h after isotope injection, but glycoprotein transport was reduced relative to normothermic controls. The reduction was especially pronounced in the most distal structure of the retinofugal tract (superior colliculus). The authors conclude that rapid axonal transport decreases with reductions in mammalian body temperature. This finding emphasizes the importance of controlling body temperature in in vivo studies of mammalian axonal transport.