Record Display for the EPA National Library Catalog


Main Title Limited Toxicity of Inhaled Acetonitrile on the Immune System of Mice with Cover Letter dated 01/26/1984 and EPA Acknowledgement dated 03/09/1984.
CORP Author Immuquest Labs., Inc., Fairfax, VA.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher Feb 1984
Year Published 1984
Report Number FYI-OTS-0284-0292-IN;
Stock Number OTS-0000292-0
Additional Subjects Mice ; Acetonitrile ; Inhalation ; Toxicity ; Immune system ; Immune response ; Atrophy ; Catalysts ; Solvents ; Hematology ; Humoral immunity ; Research ;
Library Call Number Additional Info Location Last
NTIS  OTS-0000292-0 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 28p
Hematological, cellular and humoral immune responses as well as clinical chemistry parameters of mice exposed to acetonitrile by inhalation were examined following observations that 800 ppm (10 treatment days) of this agent induced thymic atrophy in mice and rats. B(sub 6)C(sub 3)F(sub 1) mice received ten 6-hour exposures to 0, 100, 200, or 400 ppm of acetonitrile during a fourteen day period and were evaluated by a battery of immunological assays. Hematological parameters including hematocrit, hemoglobin, RBC and WBC were significantly depressed (P< 0.05) at increasing concentrations of the chemical. Lymphocyte proliferative responses to T-cell mitogens were depressed along with a somewhat depressed host susceptibility to transplantable tumor cell challenge, although neither of these responses were dose dependent. Studies of B-lymphocyte function indicated that levels of serum IgG were significantly depressed (P< 0.05) with increasing concentrations of acetonitrile while concentrations of IgA and IgM were unchanged. Other assays of B-cell function, including Cunningham plaque assay responses to sheep RBC and B-cell proliferative responses to mitogens, were not significantly altered by acetonitrile. Delayed hypersensitivity responses to keyhole limpet hemocyanin responses were not affected by acetontrile treatment.