| Main Title |
Effects of selected asbestos fibers on cellular and molecular parameters / |
| Author |
Hart, R. W. ;
Fertel, R. ;
Newman, H. A. I. ;
Daniel, F. B. ;
Blakeslee, J. R.
|
| Other Authors |
|
| CORP Author |
Ohio State University. Chemical Biomedical Environmental Research Group. |
| Publisher |
Health Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency ; Available from National Technical Information Service, |
| Year Published |
1979 |
| Report Number |
EPA-600/1-79-021; EPA-R-804201 |
| Stock Number |
PB-299 199 |
| OCLC Number |
05513539 |
| Subjects |
Asbestos fibers--Environmental aspects ;
Asbestos--Toxicology ;
Asbestos--toxicity ;
Environmental Exposure
|
| Additional Subjects |
Asbestos ;
Toxicology ;
Deoxyribonucleic acids ;
Revisions ;
In vitro analysis ;
Tissue culture ;
Laboratory animals ;
Serpentine ;
Amphiboles ;
Cellular materials ;
Molecular structure ;
Cultures(Biology) ;
Toxic substances ;
Cytoxicity ;
Carcinogenesis ;
Environmental health
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EJBD |
EPA 600-1-79-021 |
|
Headquarters Library/Washington,DC |
04/24/2014 |
| EKBD |
EPA-600/1-79-021 |
|
Research Triangle Park Library/RTP, NC |
04/17/2019 |
| ELBD ARCHIVE |
EPA 600-1-79-021 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
| NTIS |
PB-299 199 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
xi, 35 pages : charts ; 28 cm. |
| Abstract |
Embryonic cultures were used to compare the effects of five asbestos materials on a cellular, biochemical and molecular basis. Chrysotile was found to be the most cytotoxic followed by crocidolite, tremolite, amosite, and silica. Results of tests involving cellular ratios of cyclic nucleotides were consistent with asbestos acting as a promoter of carcinogenesis. Washed asbestos fibers had little or no effect on induction of DNA damage based on unscheduled DNA synthesis tests. |
| Notes |
"EPA 600/1-79-021"--Cover. "May 1979"--Cover. "Grant No. R-804201." "Project Officer James R. Millette Exposure Evaluation Branch Health Effects Research Laboratory." Includes bibliographical references. |
