Record Display for the EPA National Library CatalogRECORD NUMBER: 3 OF 14
|Main Title||Effect of Polychlorinated Biphenyls on Rat Reproduction.|
|Author||Linder, R. E. ; Gaines, T. B. ; Kimbrough., R. D. ;|
|CORP Author||Environmental Protection Agency, Chamblee, Ga. Chamblee Toxicology Lab.|
|Stock Number||PB-279 186|
|Additional Subjects||Toxicology ; Pesticides ; Bioassay ; Exposure ; Laboratory animals ; Experimental data ; Rats ; Chlorine organic compounds ; Tables(Data) ; Reproduction(Biology) ; Pathology ; Dosage ; Diets ; Mortality ; Liver ; Histology ; Lethal dosage ; Physiological effects ; Aroclor 1254 ; Reprints ; Polychlorinated biphenyls ; Aroclor 1260 ; Biphenyl/hexachloro ; Biphenyl/chloro ; Toxic substances|
The present investigation was initiated in 1970 to study the effects on reproduction and pathology produced by two American-made PCB mixtures sold under the trade-names Aroclor 1254 and Aroclor 1260. Aroclor 1254 contains 54% (w/w) chlorine and is composed of 11% tetra-, 49% penta-, 34% hexa- and 6% heptachlorobiphenyls; Aroclor 1260 has 60% (w/w) chlorine, with a composition of 12% penta-, 38% hexa-, 41% septa-, 8% octa- and 1% nonochlorobiphenyls. The present communication is an account of reproduction studies in rats. Also included are acute toxicity values from preliminary studies and comments on pathology and haematology in animals from the reproduction experiments.