||Behavioral Consequences of Chelator Administration in Acute Cadmium Toxicity (Journal Version).
Peele, D. B. ;
Farmer, J. D. ;
MacPhail, R. C. ;
||Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;Northrop Services, Inc., Research Triangle Park, NC.
Chelating agents ;
Avoidance learning ;
Animal behavior ;
Sulfhydryl compounds ;
Dimercaptosuccinic acid(DMSA) ;
Toxic substances ;
||Some EPA libraries have a fiche copy filed under the call number shown.
The conditioned flavor-aversion paradigm was used to assess the toxicity of acutely administered cadmium and the interaction of cadmium with the heavy-metal chelating agents dimercaprol (BAL) and dimercaptosuccinic acid (DMSA). Shortly after consuming saccharin, rats received cadmium either alone or in combination with BAL or DMSA. When compared to rats receiving either nothing or the vehicle, rats receiving cadmium displayed significant reductions in saccharin preference (i.e., conditioned flavor aversions). BAL and DMSA were also capable of producing conditioned flavor aversions when given alone. Rats receiving cadmium in combination with either BAL or DMSA displayed significant, but not complete, attenuations of conditioned flavor aversions when compared to rats receiving cadmium alone. Chelator-induced blockade of cadmium-induced flavor-aversion conditioning was not obtained when BAL or DMSA administration was delayed by 4 hrs. (Copyright (c) 1988 by the Society of Toxicology.)