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Main Title Experimental Pharmacokinetics and Toxicology of Acrylonitrile.
CORP Author Dortmund Univ. (Germany, F.R.). Inst. fuer Arbeitsphysiologie.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 1984
Year Published 1984
Report Number FYI-OTS-0385-0390-IN;
Stock Number OTS-0000390-0
Additional Subjects Acrylonitrile ; Pharmacokinetics ; Toxicology ; Metabolism ; Rats ; Rhesus monkeys ; Inhalation ; Toxicity ; Acute toxicity antidotes
Library Call Number Additional Info Location Last
NTIS  OTS-0000390-0 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 52p
We noticed a publication about acute acrylonitrile poisoning (case report, Texas Medicine 80, 1984) from the U.S. The authors speculate about N-acetylcysteine as antidote after accidental acrylonitrile poisoning. The toxicity of acrylonitrile may not be attributed to the liberation of cyanide. This is the reason to give you information about our studies. We observed in our experiments only minor cyanide liberation and attribute toxicity of acrylonitrile preferably to cyanoethylation of essential SH-groups. In our acute toxicity studies N-acetylcystein was the most efficient antidote. As a consequence of these works (publications enclosed) some official guidelines in West Germany were changed. You will find a brief summary of these guidelines in the paper 'Clinical Toxicology of Acrylonitrile.' We think N-acetylcysteine is much more effective than cyanide antidotes for therapy of accidental acrylonitrile poisoning on work places in the U.S.