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Main Title Morphological Transforming Activity and Metabolism of Cyclopenta-Fused Isomers of Benz(a)anthracene Mammalian Cells.
Author Mohapatra, N. ; MacNair, P. ; Bryant, B. J. ; Ellis, S. ; Rudo, K. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC.
Year Published 1987
Report Number EPA/600/J-87/171;
Stock Number PB88-160676
Additional Subjects Morphology ; Metabolism ; Cells(Biology) ; Mammals ; Reprints ; Benz(a)anthracene ; Cyclopenta fused isomers
Library Call Number Additional Info Location Last
NTIS  PB88-160676 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 14p
Cyclopenta-polycyclic aromatic hydrocarbons are a unique class of environmental PAH which contain an unsaturated five-membered ring available for metabolic alteration and metabolic activation. Previous studies with four isomeric cyclopenta-derivatives of benz(a)anthracene: benz(e)aceanthrylene, benz(j)aceanthrylene, benz(l)aceanthrylene, and benz(k)acephenanthrylene indicated that these PAH were mutagenic to Salmonella typhimurium and Chinese hamster V79 cells. In the study, these four isomeric cyclopenta-derivatives of benz(a)anthracene were examined for their ability to morphologically transform C3H10T1/2CL8 mouse embryo fibroblasts. All of the PAH studied except benz(k)acephenanthrylene transformed C3H10T1/2CL8 cells to both type II and type III foci in a concentration-dependent fashion. Benz(j)aceanthrylene was the most active, equivalent in activity to benzo(a)pyrene on a molar basis, in producing dishes of cells with transformed foci (94% at 1.0 micrograms/ml). Benz(e)aceanthrylene, and benz(l)aceanthrylene produced 58% and 85% of the dishes with foci respectively at 10 micrograms/ml.