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Main Title Factors Associated with Reduced Fertility and Implantation Rates in Females Mated to Acrylamide Treated Rats.
Author Sublet, V. H. ; Zenick, H. ; Smith, M. K. ;
CORP Author Health Effects Research Lab., Cincinnati, OH. ;Cincinnati Univ., OH. Dept. of Environmental Health.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-89/062;
Stock Number PB90-103680
Additional Subjects Fertility ; Toxicity ; Acrylamide ; Rats ; Male ; Female ; Reproduction(Biology) ; Germ cells ; Dose rate ; Reprints ; Animal sex behavior ; Fertilization ; Ovum implantation
Library Call Number Additional Info Location Last
NTIS  PB90-103680 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 17p
A series of studies was conducted to examine the role of copulatory dysfunction, spermatotoxicity, and/or impaired fertilization in the reduced rates of fertility and implantation observed in females mated to acrylamide-treated male rats. In initial experiments, males were gavaged with 0, 5, 15, 30, 45, or 60 mg/kg acrylamide (ACR) for 5 days and then mated serially to naive females. ACR treatment reduced fertility and increased pre- and post-implantation loss, primarily over the first 3 weeks post-treatment. The data suggest that events critical to the fertilizing ability of the sperm appear to play a major role in the reduced reproductive competence associated with ACR treatment in male rats. (Copyright (c) 1989 Elsevier Scientific Publishers Ireland Ltd.)