Record Display for the EPA National Library Catalog


Main Title Teratogenic Activity of Trichloroacetic Acid in the Rat.
Author Smith, M. K. ; Randall, J. L. ; Read, E. J. ; Stober, J. A. ;
CORP Author Pathology Associates, Inc., Cincinnati, OH. ;Computer Sciences Corp., Cincinnati, OH.;Health Effects Research Lab., Cincinnati, OH.
Publisher c1989
Year Published 1989
Report Number EPA-68-03-002; EPA/600/J-89/333;
Stock Number PB90-199423
Additional Subjects Toxicology ; Rats ; Body weight ; Tables(Data) ; Embryos ; Reprints ; Teratogens ; Trichloroacetic acid ; Gestation ; Organ weight ; Animal pregnancy ; Dose-response relationships
Library Call Number Additional Info Location Last
NTIS  PB90-199423 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
Trichloroacetic acid (TCA) is a by-product of the chlorine disinfection of water containing natural organic material. It is detectable in finished drinking water at levels comparable to the trihalomethanes (30-160 microg/L). TCA is also formed in vivo after ingestion of hypochlorite and has been identified as a major metabolite of chlorinated hydrocarbons such as trichloroethylene. The developmental effects of TCA were evaluated in the pregnant Long-Evans rat. Animals were dosed by oral intubation on gestation days 6-15 (plug = 0) with 0, 330, 800, 1,200, or 1,800 mg/kg/day. Live fetuses were examined for external, skeletal, and soft tissue malformations. There were no maternal deaths associated with toxicity prior to sacrifice. Weight gain during treatment was reduced at 800, 1,200, and 1,800 mg/kg. Spleen and kidney weights were increased in a dose-related manner. Skeletal malformations were found only at 1,200 and 1,800 mg/kg and were mainly in the orbit. Based on these observations TCA was considered to be developmentally toxic in the pregnant rat at doses of 330 mg/kg and above. (Copyright (c) 1989 Alan R. Liss, Inc.)