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Main Title The in-vivo metabolism of pentachloroaniline in rhesus monkeys /
Author Leber, A. Philip. ; Freudenthal., R. I.
Other Authors
Author Title of a Work
Freudenthal, Ralph I.
Baron, Ronald L.,
Leber, A. Philip.
Freudenthal, R. I.
CORP Author United States. Environmental Protection Agency.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory
Year Published 1976
Report Number EPA-600/1-76-031; EPA-68-02-1715
Stock Number PB 259 929
OCLC Number 48644170
Subjects Pesticides--toxicity ; Neurotoxins ; Pesticides--toxicity--Congresses
Additional Subjects Isotopic labeling ; Fungicides ; Toxicology ; Amines ; Chlorine organic compounds ; In vivo analysis ; Tables(Data) ; Rhesus monkeys ; Metabolism ; Laboratory animals ; Dosage ; Absorption(Biology) ; Physiological effects ; Pesticides ; Pharmacology ; Aniline/pentachloro ; Metabolites
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EIAD  EPA-600/1-76-031 Region 2 Library/New York,NY 06/27/2003 DISPERSAL
EJBD ARCHIVE EPA 600-1-76-031 Headquarters Library/Washington,DC 02/06/2012
EJBD  EPA 600-1-76-031 Headquarters Library/Washington,DC 04/08/2014
EKBD  EPA-600/1-76-031 Research Triangle Park Library/RTP, NC 06/20/2003
ELBD  EPA 600-1-76-031 AWBERC Library/Cincinnati,OH 03/01/2021
NTIS  PB-259 929 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation iv, 33 pages : illustrations ; 28 cm.
The metabolism of pentachloroaniline was determined in the rhesus monkey. 14C-pentachloroaniline was orally administered to five rhesus monkeys. Blood, urine and feces were collected at designated times following dosing. The radioactive material in the biological samples was extracted and then separated by chromatographic procedures. The chemical structure of the major metabolite was characterized by mass spectrometry and nuclear magnetic resonance spectrometry, using a chemically synthesized reference standard. Radioactivity levels in the blood samples indicate large variation between individual animals with respect to rate of absorption and time of peak plasma radioactivity. Urinary excretion accounts for 33 to 67 percent of the administered dose while from 6 to 15 percent is excreted in the feces.
"Contract No. 62-02-1715." "Project officer, Dr. Ronald L. Baron." "EPA-600/1-76-031." "September 1976." Includes bibliographical references.