||Significances of the Variability of Airway Paths and Their Air Flow Rates to Dosimetry Model Predictions of the Absorption of Gases.
Overton, J. H. ;
Barnett, A. E. ;
Graham, R. C. ;
||Northrop Services, Inc., Research Triangle Park, NC.;Environmental Protection Agency, Research Triangle Park, NC. Inhalation Toxicology Div.
||EPA/600/D-87/364; EPA-68-02-4450; EPA/600/D-87/364;
Anatomical models ;
Air flow ;
Respiratory system ;
||Some EPA libraries have a fiche copy filed under the call number shown.
The ozone dosimetry model developed at EPA was developed to be used in conjunction with species lung models that summarize the structure of a lung as a lung of many equivalent paths. The paper reports the results of a preliminary study into the question of whether or not more realistic lung structures and airflow rates in individual airways need to be taken into account in order to make more accurate predictions of ozone uptake. The results indicate that in order to obtain a better understanding of the distribution of absorbed ozone in the lower respiratory tract (LRT), realistic lung structures need to be taken into account. Whereas, estimating LRT dose using a lung model composed of equivalent paths was found to give the same results obtained as when the complex lung structure was taken into account. The information will allow for a better use of experimental uptake data for the evaluation of dosimetry model predictions as well as for improved interpreting of toxicological data.