Record Display for the EPA National Library Catalog

RECORD NUMBER: 3 OF 5

Main Title Exposure of Humans to Carbon Monoxide Combined with Ingestion of Diphenhydramine Hydrochloride or Phenacetin.
CORP Author Medical Coll. of Wisconsin, Milwaukee. Dept. of Environmental Medicine.;Coordinating Research Council, Inc., New York.
Year Published 1974
Report Number MCOW-ENVM-CO-74-1; APRAC-CAPM-3-68; CRC-APRAC-CAPM-3-68-5;
Stock Number PB-242 098
Additional Subjects Carbon monoxide ; Drugs ; Phenacetin ; Toxicity ; Exposure ; Air pollution ; Health ; Pharmacology ; Analgesics ; Antihistamines ; Performance(Human) ; Synergism ; Carbonylhemoglobin ; Air pollution effects(Humans) ; Diphenhydramine
Internet Access
Description Access URL
https://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=9100KQDQ.PDF
Holdings
Library Call Number Additional Info Location Last
Modified		 Checkout
Status
NTIS  PB-242 098 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 81p
Abstract
The synergistic effect of CO and two commonly prescribed drugs, phenacetin and diphenhydramine hydrochloride were evaluated. The COHb saturation tested was 14 percent (above average for cigarette smokers), while drug doses were those usually prescribed. No synergistic effects were observed in the study. Three additional observations were made: (1) the occurrence of CO induced headaches at COHb saturations of 14 percent; (2) the possible effect of CO exposure on EEG activity at this level; and (3) the finding that phenacetin, as an analgesic, did not lessen the headaches induced by the CO exposure.