Record Display for the EPA National Library Catalog


Main Title Restraint-Induced Analgesia in the CD-1 Mouse: Interactions with Morphine and Time of Day.
Author Miller., D. B. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1988
Year Published 1988
Report Number EPA/600/J-88/540;
Stock Number PB91-109215
Additional Subjects Morphine ; Pharmacology ; Analgesia ; Diurnal variations ; Mice ; Constraining ; Tolerances(Physiology) ; Stress(Physiology) ; Reprints ; Dose-response relationships
Library Call Number Additional Info Location Last
NTIS  PB91-109215 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
The tail-flick response of adult male CD-1 mice was used to assess the analgesic properties of restraint alone and in combination with morphine during the diurnal and nocturnal periods. Mice were restrained in conical metal devices that allowed a change in position from supine to prone but not from front to back. Restraint induced an analgesia equipotent to a 2.5 mg/kg dose of morphine within 0.5 hr of its initiation. Although habituation occurred over the restraint period a pronounced analgesia was still evident at the end of the 3-hr test period. The habituation to restraint-induced analgesia was more rapid at night. Although the basal tail-flick latency to thermal stimulation was decreased during the nocturnal period the time of day did not alter the degree of analgesia induced by either restraint or morphine. Morphine induced a dose and time-dependent analgesia during both the diurnal and nocturnal periods and this analgesia was potentiated by restraint stress only during the nocturnal period. (Copyright (c) 1988 Elsevier Science Publishers B. V. (Biomedical Division.))