Record Display for the EPA National Library Catalog

RECORD NUMBER: 24 OF 38

Main Title Interactions of various pollutants on causation of pulmonary disease /
Author Ehrlich, Richard,
Other Authors
Author Title of a Work
Ehrlich, Richard,
Gardner, Donald E.,
CORP Author IIT Research Inst., Chicago, IL.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
Year Published 1978
Report Number EPA-600/1-78-057; EPA-68-02-2274
Stock Number PB-288 363
OCLC Number 52473331
Subjects Air--Pollution--Health aspects ; Pollutants--Health aspects
Additional Subjects Respiratory diseases ; Toxicology ; Streptococcus ; Air pollution ; Interactions ; Exposure ; Infectious diseases ; Resistance ; Public health ; Mice ; Bacteria ; Pneumonia ; Enzymes ; Concentration(Composition) ; Nitrogen dioxide ; Ozone ; Tolerances(Physiology) ; Sulfur dioxide ; Ammonium sulfate ; Zinc sulfates ; Recommendations ; Experimental data ; Laboratory animals ; Toxic substances ; Infections ; Air pollution effects(Humans) ; Synergism ; Animal models ; Streptococcus pyogenes ; Environmental health
Internet Access
Description Access URL
https://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=91013XR1.PDF
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
EJBD  EPA 600-1-78-057 c.1 Headquarters Library/Washington,DC 06/09/2014
EKBD  EPA-600/1-78-057 Research Triangle Park Library/RTP, NC 06/20/2003
ELBD ARCHIVE EPA 600-1-78-057 Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
ELBD RPS EPA 600-1-78-057 repository copy AWBERC Library/Cincinnati,OH 04/16/2018
NTIS  PB-288 363 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation x, 49 pages : illustrations ; 28 cm
Abstract
Studies were conducted to determine the effects of single and multiple exposures to individual and pollutant mixtures on resistance to respiratory infections. Results of NO2 studies indicate the greater importance of short-term peak concentrations than prolonged exposures to lower concentrations in increasing the susceptibility to infections. Single 3-hr exposure to mixtures containing various concentrations of NO2 and O3 had an additive effect. Repeated 3-hr exposures for 4 weeks to mixtures consisting of 3760 micrograms/cu m NO2 and 98 micrograms/cu m O3 suggested a synergistic interaction between the two pollutants. Daily 3-hr exposures for 6 months to mixtures of 940 micrograms/cu m NO2 and 196 micrograms/cu m O3 resulted in significant excess mortality, and reduced mean survival time in infected animals. Continuation of exposure to the pollutants for 14 days after the infectious challenge resulted in a pronounced increased susceptibility to the respiratory infection, after 1, 2 or 3 month exposure. In non-infected mice this exposure regimen induced changes in the activity of several serum enzymes.
Notes
Project Officer: Donald E. Gardner. IIT Research Institute Contract Number: 68-02-2274 "August 1978." "EPA-600/1-78-057." Includes bibliographical references.