Record Display for the EPA National Library Catalog


Main Title Letter from 3M to USEPA regarding Mechanistic Two-year Study of Hepatic Tumor Induction in Rats Fed Ammonium Perfluoroalkyl Carboxylates dated 10/11/93.
CORP Author Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1993
Report Number 89-941000007
Stock Number OTS0204926-4
Additional Subjects Toxicology ; Health effects ; Mixture of Ammonium Perfluorooctanoate ; Chronic Toxicity ; Combined Chronic Toxicity/carcinogenicity ; Mammals ; Rats ; Oral ; Diet ; Toxic substances ; Laboratory animals ; CAS No 3825-26-1 ; CAS No 6130-43-4 ; CAS No 21615-47-4 ; CAS No 68259-11-0
Library Call Number Additional Info Location Last
NTIS  OTS0204926-4 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
The test substance included ammonium perfluoroalkyl carboxylates (CAS No. 68259-11-0) which contains 93 to 97% ammonium perfluorooctanoate (CAS No. 3825-26-1), and smaller amounts of ammonium perfluoroheptanoate (CAS No. 6130-43-4) and ammonium perfluorohexanoate (CAS No. 21615-47-4). The test substance was investigated in a mechanistic bioassay investigating extra hepatic tumor induction by compounds which induce peroxisome proliferation. In this mechanistic bioassay, 300 ppm of the test substance was fed to rats as part of their diet for 2-years. In addition to an ad libitum control, a second control group was pair-fed to the 300 ppm test group to control for the effects of reduced body weight. Increased incidences of combined (single, multiple) hepatic adenomas, Leydig cell adenomas, and pancreatic acinar cell adenomas were seen in the 300 ppm test group when compared to either the ad libitum or pair-fed controls. The tumor incidences (liver, testis, pancreas) were outside the historical control incidence range for DuPont Haskell Laboratory. In addition, age- adjustment statistics also support the conclusion that the tumor incidence was elevated for the liver (both controls), pancreas (pair-fed control), and testis (pair-fed control).