Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Yohimbine Attenuates the Delayed Lethality Induced in Mice by Amitraz, a Formamidine Pesticide.
Author Moser, V. C. ; MacPhail, R. C. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/J-85/306;
Stock Number PB86-162310
Additional Subjects Pesticides ; Lethal dosage ; Mice ; Laboratory animals ; Reprints ; Yohimbine ; Amitraz
Library Call Number Additional Info Location Last
NTIS  PB86-162310 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 8p
The authors have found that a single dose of amitraz, a formamidine pesticide, produces death in mice which begins about two days after dosing and continues for up to 5 more days. To further examine the phenomenon, adult albino mice of both sexes were treated with either yohimbine (10 mg/kg, i.p.) or deionized water (6 ml/kg, i.p.), immediately before an injection of amitraz (600 mg/kg, i.p.) and twice daily thereafter for eight days. Male mice treated with water were more susceptible than water-treated females to the lethal effects of amitraz. In addition, yohimbine treatment significantly decreased the number of deaths in both sexes. These data suggest that an 2-adrenergic mechanism is involved in the delayed lethality produced by amitraz.