||Computer-Automated Sequence Evaluation of Peptides: Application to the Study of Snake Venom Toxicity.
Klopman, G. ;
Venegas, R. E. ;
||Case Western Reserve Univ., Cleveland, OH. Dept. of Chemistry.;Health Effects Research Lab., Research Triangle Park, NC.;Office of Naval Research, Arlington, VA.
||EPA-R-812264, N0014-85-K-0090; EPA/600/D-89/136;
Snake venoms ;
Amino acid sequence ;
Structure-activity relationship ;
Computer automated structure evaluation(CASE)
||Some EPA libraries have a fiche copy filed under the call number shown.
A modified version of the Computer Automated Structure Evaluation (CASE) program has been successfully applied to the study of the neurotoxic and cytotoxic activity of the snake venom toxins. The program identified the sites that seem to be the most relevant to the activity of these two classes of peptides. The knowledge of the three dimensional structure of these peptides together with the relevant fragments selected by the CASE program helped to clarify the differences between the activity of each type of toxin. (Copyright (c) 1989 American Chemical Society.)