Record Display for the EPA National Library Catalog


Main Title Computer-Automated Sequence Evaluation of Peptides: Application to the Study of Snake Venom Toxicity.
Author Klopman, G. ; Venegas, R. E. ;
CORP Author Case Western Reserve Univ., Cleveland, OH. Dept. of Chemistry.;Health Effects Research Lab., Research Triangle Park, NC.;Office of Naval Research, Arlington, VA.
Publisher c1989
Year Published 1989
Report Number EPA-R-812264, N0014-85-K-0090; EPA/600/D-89/136;
Stock Number PB90-113085
Additional Subjects Toxicity ; Peptides ; Reprints ; Snake venoms ; Amino acid sequence ; Neurotoxins ; Structure-activity relationship ; Computer automated structure evaluation(CASE)
Library Call Number Additional Info Location Last
NTIS  PB90-113085 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 17p
A modified version of the Computer Automated Structure Evaluation (CASE) program has been successfully applied to the study of the neurotoxic and cytotoxic activity of the snake venom toxins. The program identified the sites that seem to be the most relevant to the activity of these two classes of peptides. The knowledge of the three dimensional structure of these peptides together with the relevant fragments selected by the CASE program helped to clarify the differences between the activity of each type of toxin. (Copyright (c) 1989 American Chemical Society.)