Record Display for the EPA National Library Catalog


Main Title Effect of Silica and Volcanic Ash on the Content of Lung Alveolar and Tissue Phospholipids.
Author Kornbrust, D. J. ; Hatch, G. E. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Research Triangle Inst., Research Triangle Park, NC.
Year Published 1984
Report Number EPA/600/J-84/362;
Stock Number PB86-175379
Additional Subjects Silicon dioxide ; Volcanic ejecta ; Toxicology ; Lung ; Pathology ; Rats ; Laboratory animals ; Alveoli ; Phospholipids ; Reprints ; Air pollution effects(Animals)
Library Call Number Additional Info Location Last
NTIS  PB86-175379 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 16p
Silica or volcanic ash (VA) was administered to rats via intratracheal instillation and the changes in extracellular (i.e., lavage fluid) and tissue phospholipids, as well as various biochemical parameters, were monitored over a six month period. VA produced relatively minor (up to 2.8-fold) increases in lung tissue or lavage fluid phospholipids that were maximal at one month post-instillation. These increases were quantitatively similar to the increases in protein and DNA content of lung tissue and lavage fluid induced by VA and, thus, may be attributable to hypercellularity and accumulation of cellular breakdown products in the alveolar lumen. Instillation of silica produced a much greater (up to 11-fold) increase than VA in total phospholipid over time, primarily due to a 14-fold increase in phosphatidylcholine (PC). The accumulation of PC was more pronounced in the lavage fluid during the first month following silica instillation, but thereafter progressed more rapidly in the lung tissue.