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Main Title Human clinical inhalation exposures experimental design, methodology, and physical responses. {microfiche}
Author Folinsbee, L.J.
CORP Author Environmental Monitoring and Services, Inc., Chapel Hill, NC. ;North Carolina Univ. at Chapel Hill. Dept. of Medicine.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher Environmental Monitoring and Services,
Year Published 1991
Report Number EPA/600/D-90/171
Stock Number PB91-132944
Additional Subjects Air pollution ; Respiration ; Physiology ; Design ; Allergies ; Asthma ; Exercise(Physiology) ; Reprints ; Toxic substances ; Environmental exposure pathways ; Respiratory function tests ; Dose-response relationships
Library Call Number Additional Info Location Last
NTIS  PB91-132944 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Edition 1st ed.
Collation 27 p. : ill. ; 23 cm.
Knowledge of the effects of inhaled pollutants on man is the underlying purpose of research in inhalation toxicology. Specifically, the aims of the chapter are to summarize some experimental design issues, illustrate them with study results demonstrating the use of certain procedures, and discuss the importance of particular methodology. Several important factors in the design and implementation of human exposure studies have been addressed by other reviewers. It is not the author's intent to provide a comprehensive review of either methodology or the pulmonary responses of man to air pollutants, neither of which is feasible in a brief chapter. The results of many investigations of ambient or toxic air contaminants have been and will be used in the establishment of air quality standards. Therefore, certain aspects of experimental design, such as subject selection and characterization, description of symptoms, and details of mode of exposure, require specific attention to elucidate the relevance of these studies to ambient exposure conditions.