||Method of Determining Allergenic Properties of Chemical Substances (K Metodike Opredeleniya Allergennykh Svoistv Khimicheskikh Veshchestv).
Alekseeva, O. G. ;
Petkevich., A. I. ;
||Environmental Protection Agency, Research Triangle Park, N.C. Translation Services Section.
Allergic diseases ;
Chemical compounds ;
Diagnostic agents ;
Experimental data ;
Guinea pigs ;
Laboratory animals ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
A single injection into the skin of the ear of 0.02 ml of dilutions of all 6 tested allergens (from 1:500 and above) sensitized guinea pigs in 11-12 days. The allergenic activity of chemical substances can be compared by their dilution in the sensitizing injection. As the suggested method is based on the injection of large dilutions of the tested substances, it can be used to study poorly soluble products and a small amount of the injected allergen guarantees against intoxication, which weakens the development of allergy.