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Main Title Initial Submission: Letter from Rohm and Haas, Co. to USEPA re: Preliminary Results including Neurotoxicity from Acute Oral Toxicity Study in Rats with (Confidential Information), an Alkynyl Chloride, dated 11/08/99 (Sanitized).
CORP Author Rohm and Haas Co., Philadelphia, PA.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 15 Nov 1999
Year Published 1999
Report Number 8EHQ-1199-14590S;
Stock Number OTS-0559837
Additional Subjects Toxicity ; Neurotoxicity ; Rats ; Laboratory animals ; Males ; Females ; Dosage ; Mortality ; Gavage ; Skin(Anatomy) ; Alkynyl chloride ; Acute oral toxicity
Library Call Number Additional Info Location Last
NTIS  OTS-0559837 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 7p
This letter transmits preliminary results of a acute toxicity test indicating neurotoxic effects to male and female rats for alkynyl chloride. Undiluted alkynyl chloride was administered as a single oral dose (gavage) to three groups of six male and six female rats at dose levels of 500, 1000, or 1500 mg/kg of body weight. Clinical signs indicative of neurotoxicity (i.e., ataxia, fasciculations, prostration, salvation, lacrimation, tremors, nystagmus and/or dragging of hind limbs) were observed among survivors and decedents at all dose levels. These signs were noted beginning at one hour and continued through day 7. Dose related mortality occurred in this study 0/6 males and 3/6 females at 500 mg/kg; 3/6 males and 6/6 females at 1000 mg/kg; and 6/6 males and 6/6 females at 1500 mg/kg. All deaths occurred by day 3 post-dosing. The test substance, as received, was applied to the shaved intact skin of three groups of six male and female rats at 400, 1200 or 3600 mg/kg body weight. The application sites were occluded for 24 hours.