Record Display for the EPA National Library CatalogRECORD NUMBER: 22 OF 25
|Main Title||Respiratory Responses to Repeated Prolonged Exposure to 0.12 ppm Ozone.|
|Author||Folinsbee, L. J. ; Horstman, D. H. ; Kehrl, H. R. ; Harder, S. ; Abdul-Salaam, S. ;|
|CORP Author||Health Effects Research Lab., Research Triangle Park, NC. Clinical Research Branch. ;ABB Environmental Services, Inc., Chapel Hill, NC.|
|Additional Subjects||Ozone ; Air pollution effects(Humans) ; Lung ; Exposure ; Airway resistance ; Vital capacity ; Signs and symptoms ; Spirometry ; Exercise(Physiology) ; Methacholine chloride ; Respiratory function tests ; Dose-response relationships ; Toxicity ; Nasal lavage fluid ; Plethysmography ; Reprints ; Aerosol bolus|
Repeated exposures to high concentrations of ozone results first in augmentation and then attenuation of pulmonary response in humans. To determine the effects of repeated prolonged low concentration ozone exposure, we exposed 17 healthy, non-smoking males to 0.12 ppm ozone for 6.6 h on five consecutive days. Subjects were also exposed once to filtered air. Volunteers exercised at a ventilation of -39 L/min for 50 min of each hour during the exposure. Spirometry, plethysmography, and symptom responses were obtained before and after each exposure. Nasal lavage and aerosol bolus dispersion were obtained before and after each exposure. Spirometry decreased and symptoms increased on the first day. Responses were less on the second day compared to the first, and were absent, compared to control, on the subsequent three days of ozone exposure.