Record Display for the EPA National Library Catalog


Main Title Acute Vapor Inhalation Toxicity Study in Rats with Cover Letter.
CORP Author Industrial Bio-Test Labs., Inc., Northbrook, IL. ;Occidental Chemical Corp., Niagara Falls, NY.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 27 Jan 1983
Year Published 1983
Report Number 878212097;
Stock Number OTS-0205956
Additional Subjects Vapors ; Inhalation ; Toxicity ; Rats ; Necropsies ; Exposure ; Death ; Body weight ; Mortality ; Pathology ; Pneumonia ; Consolidation ; Inflammatory diseases ; Lungs ; Air pressure ; Air flow ; Laboratory animals ; Testing ; Hexachlorocyclopentadiene ; Occidental Chemical Corporation
Library Call Number Additional Info Location Last
NTIS  OTS-0205956 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 373p
Complete necropsies were done on all surviving rats on termination of the study. Similar examinations were done as quickly after death as possible on rats that died during the experiment. Three male rats and one female rat in test group I, four male rats and two female rats in test group II, five male rats and four female rats in test group III and all rats in test group IV died during the experiment. Acute pneumonia characterized by varying degrees of consolidation (Hepatization) was observed in rats that died shortly after exposure to the test material. Treated rats that survived to completion of the study were described as emaciated. Frequently, the lungs of these animals did not collapse when the thorax was opened. This suggests a chronic proliferative inflammatory response in the lungs of affected animals.