||Inhalation toxicology of airborne particulate manganese in Rhesus monkeys /
Coulston, Frederick ;
||Albany Medical Coll., N.Y. Inst. of Comparative and Human Toxicology. ;International Center of Environmental Safety, Holloman AFB, N. Mex.;Health Effects Research Lab., Research Triangle Park, N.C.
|| U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
||PB268643; EPA-600/1-77-026; EPA-68-02-0710
Manganese oxides ;
Air pollution ;
Experimental data ;
Laboratory animals ;
Rhesus monkeys ;
Clinical chemistry ;
Air pollution effects(Animals)
||OCSPP Chemical Library/Washington,DC
||Research Triangle Park Library/RTP, NC
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||vi, 85 pages ; 28 cm.
Four male and four female rhesus monkeys were exposed to manganese oxide (Mn3O4) aerosol at 100 micrograms/cubic meter in an exposure chamber for periods up to 66 weeks. Three male and three female monkeys were maintained as unexposed controls. Observation and clinical chemistry during the experiment showed minor changes in excretion, and no evidence of toxic effects. Manganese tissue levels showed small increases except in lung (five-fold) and pons (four-fold). No macro- or microscopic pathology was observed. Two rhesus monkeys were exposed to 5 mg/cubic meter of the same material for 23 weeks, and observed for 10 months thereafter. Large increases in excretion of manganese were observed in both urine and feces, but no evidence of neurologic or other toxicity was seen. Two groups of 4 and of 14 rats were exposed in the same manner to 100 micrograms/cubic meters of the same compound for 8 weeks. These experiments were done to examine changes in excretion and tissue levels during and after exposure.
Project Officer: John H. Knelson and Gory J. Love. "May 1977." "EPA-600/1-77-026." PB 268 643--NTIS. Includes bibliographical references.