Record Display for the EPA National Library Catalog

RECORD NUMBER: 36 OF 39

OLS Field Name OLS Field Data
Main Title Some Constitutive Modifiers of the Kinetic and Dynamic Behavior of Non-Essential Metals.
Author Thomas, D. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div.
Publisher 23 Jul 92
Year Published 1992
Report Number EPA/600/A-89/189;
Stock Number PB92-227347
Additional Subjects Pharmacokinetics ; Metals ; Metabolism ; Nutrition ; Toxicology ; Cadmium ; Mercury ; Aging(Biology) ; Lead ; Metallothionein ; Messenger RNA ; Sex factors ; Genotype ;
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB92-227347 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/01/1993
Collation 23p
Abstract
In addition to the variety of extrinsic (e.g., environmental, nutritional and experimental) factors which can influence the kinetic and dynamic behavior of non-essential metals, certain intrinsic or constitutive characteristics of the host organism can influence the distribution, metabolism and toxic effects of these metals. An important task in metal toxicology is identification of these constitutive factors and elucidation of the molecular bases of organismic differences in the kinetic and dynamic behavior of non-essential metals. Understanding of these differences increases the knowledge of the physiological processes controlling metal disposition and improves the accuracy of the assessment of hazard associated with exposure to non-essential metals. The incorporation of these constitutive factors into the modelling of the kinetic behavior of non-essential metals will improve the descriptive and predictive value of the models.