Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Effects of Chlordimeform on Cardiovascular Functional Parameters. Part 1. Lethality and Arrhythmogenicity in the Geriatric Rat.
Author Watkinson, W. P. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/J-85/489;
Stock Number PB87-194544
Additional Subjects Pesticides ; Amidines ; Aging(Biology) ; Cardiac arrhythmias ; Heart diseases ; Cardiovascular diseases ; Geriatrics ; Rats ; Blood pressure ; Electrocardiography ; Reprints ; Chlorphenamidine ; Arrhythmia ; Heart rate
Library Call Number Additional Info Location Last
NTIS  PB87-194544 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 19p
Chlordimeform (CDM), a formamidine pesticide, had a profound effect on the cardiovascular function of geriatric rats. Two-year-old pentobarbital-anesthetized Sprague-Dawley rats (n=8) received sequential intravenous CDM injections of 5, 10, 30, and 60 mg/kg. A control group of rats (n=8) received multiple injections of normal saline vehicle over a similar time period, followed by a single CDM injection of 60 mg/kg. Heart rate (HR), arterial blood pressure (BP), and electrocardiogram (ECG) were monitored for all animals. CDM produced abrupt decreases in HR and BP at all doses. In addition, striking changes in ECG waveforms and intervals and various conduction-related arrhythmias were observed. These acute effects triggered a reflex-mediated overshoot in HR and BP above preinjection levels, followed by a delayed, persistent depression of these parameters. Three animals from the CDM-treated group died after injection of the 30-mg/kg dose, while 60 mg/kg was lethal in the remaining animals. In the majority of cases, death appeared to be due to cardiac arrest.