||Effect of the Age of B6C3F1 Mice on Phenobarbital Promotion of Diethylnitrosamine Initiated Liver Tumors.
Klaunig, J. E. ;
Weghorst, C. M. ;
Pereira, M. A. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Medical Coll. of Ohio at Toledo. Dept. of Pathology.
Liver neoplasms ;
Nitroso compounds ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
Chronic exposure to phenobarbital (PB) in the drinking water of male B6C3F1 mice starting at 4 weeks of age and subsequent to a single (ip) injection of diethylnitrosamine (DENA) administered on Day 15 of age has been shown to result in the inhibition of hepatic tumor formation. In the study, the authors varied the time of onset of PB administration to determine if sexual maturity would affect liver tumor formation and progression. Data from the study suggest that the inhibition of hepatocellular tumorigenesis by PB remains intact even when the start of the administration of PB is withheld up to 12 weeks of age. (Copyright (c) 1987 Academic Press, Inc.)