||Aerosol Generator System for Inhalation Delivery of Pharmacologic Agents.
Strong, A. A. ;
Hazucha, M. J. ;
Lundgren, D. A. ;
Cerini, E. R. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. ;Florida Univ., Gainesville. ;Naval Facilities Engineering Command, Alexandria, VA.
Aerosol generators ;
Particle size distribution ;
Medical equipment ;
||Some EPA libraries have a fiche copy filed under the call number shown.
Most commercially available aerosol generators for medical applications produce aerosols characterized by a broad particle size distribution and a large mass median (MMD). The desirable size of therapeutic and diagnostic aerosols is about 2-4 micrometers MMD with a narrow and uniform distribution. The size enhances testing reproducibility and the evaluation of drug efficacy. Researchers combined the commercially available DeVilbiss 65 nebulizer with a mixing/dilution chamber developed in the laboratory. The characteristics of this aerosol generator system (AGS) were examined over a range of operating conditions and concentrations of solutions of three bronchoconstrictive agents, histamine, carbachol and methacholine. The AGS produced a polydispersed aerosol with a MMD range of 1.7 to 2.4 micrometers and a Sg 1.5. The reliable and reproducible operation of the AGS greatly increases the power of bronchial challenge tests with bronconstrictive drugs. (Copyright (c) 1987 by the Association for the Advancement of Medical Instrumentation.)