||Norepinephrine Modulates the Growth-Inhibitory Effect of Transforming Growth Factor-Beta in Primary Rat Hepatocyte Cultures.
Houck, K. A. ;
Cruise, J. L. ;
Michalopoulos, G. ;
||Duke Univ. Medical Center, Durham, NC. Dept. of Pathology.;Health Effects Research Lab., Research Triangle Park, NC.
Deoxyribonucleic acids ;
Transforming growth factors ;
Epidermal growth factor-urogastrone receptors ;
Dose-response relationships ;
Alpha adrenergic receptors ;
||Some EPA libraries have a fiche copy filed under the call number shown.
TGF-beta is a potent inhibitor of EGF-induced DNA synthesis in primary rat hepatocyte cultures. Norepinephrine (NE) was shown to modulate this inhibition of DNA synthesis. It produced a five-fold increase, from 2.8 pM to 14.4 pM, in the ID(sub 50) for TGF-beta. The effect was dose-dependent and was significant at concentrations of 10(sup -6)M NE and greater. The modulation by NE was medicated by the alpha(1)-adrenergic receptor as shown by the ability of the alpha(1) antagonist prazosin to block the activity. This effect might be important during liver regeneration in allowing escape of hepatocytes from negative growth control exerted by TGF-beta (Copyright (c) 1988 Alan R. Liss, Inc.)