| Main Title |
Alpha(2)-Adrenergic Mode of Action of Chlordimeform on Rat Visual Function. |
| Author |
Boyes, W. K. ;
Moser, V. C. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC. |
| Year Published |
1988 |
| Report Number |
EPA/600/J-88/039; |
| Stock Number |
PB88-225768 |
| Additional Subjects |
Insecticides ;
Acaricides ;
Adrenergics ;
Visual perception ;
Central nervous system ;
Laboratory animals ;
Chlorine organic compounds ;
Amidines ;
Reprints ;
Chlordimeform ;
Adrenergic alpha receptors ;
Toxic substances ;
Visual evoked potentials ;
CAS 6164-98-3 ;
Formamidine/chloro-tolyl-dimethyl
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-225768 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
17p |
| Abstract |
The hypothesis that chlordimeform increased the amplitude of components N;P1 and P1N3 in rat pattern-reversal visual evoked potentials through actions on alpha2 adrenergic receptors was tested. Yohimbine alone had no effect on pattern-reversal evoked potential amplitude. Clonidine treatment produced a dosage related increase in amplitude of both components similar to that produced by chloroimeform. Yohimbine pretreatment attenuated the effects of subsequent treatment with either clonidine or chlordimeform. The results support the hypothesis that chlordimeform alters rat pattern-reversal evoked potentials through actions as a central nervous system alpha2 adrenergic agonist. (Copyright (c) Academic Press, Inc.) |
