||Changes in Lung ATP (Adenosine Triphosphate) Concentration in the Rat After Low-Level Phosgene Exposure (Journal Version).
Currie, W. D. ;
Hatch, G. E. ;
Frosolono, M. F. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Duke Univ. Medical Center, Durham, NC. ;Burroughs Wellcome Co., Research Triangle Park, NC.
Toxic substances ;
Adenosine triphosphate ;
Laboratory animals ;
Pulmonary edema ;
Dose-response relationships ;
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Rats were exposed to phosgene for 4 hrs at concentrations of 0.05 to 1.0 ppm. Lung wet and dry wt and ATP concentration were measured immediately after exposure and for 3 days post-exposure. The accumulation of lavage fluid protein (LFP) was also measured as an index of damage or edema due to phosgene. Lung wt (wet and dry) was significantly elevated one day post-exposure to 0.5 ppm phosgene while LFP was elevated at a lower concentration. The ATP decrease was found to be phosgene concentration-dependent and remained decreased for 3 days post-exposure to 1.0 ppm. Time course studies at these doses of phosgene showed that decreased ATP concentration preceded the onset of edema or increase in lung weight. The ATP values expressed on a per lung basis showed that ATP levels were significantly lowered immediately following phosgene exposure, suggesting that the ATP changes were not the result of edema. (Copyright (c) 1987 VCH Publishers, Inc.)